The castle church, the most significant late Gothic building in the Nahe region, was constructed between 1479 and 1504 by master builder Philipp von Gmünd. Art historically, it is the most important building in Meisenheim.
It, together with the Herzog-Wolfgang-Haus, forms the only preserved remnant of the former castle. The three-nave hall church features a magnificent tower with a pierced tower helmet. Noteworthy are the ornate vaults, especially the freely floating vault ribs in the Wittelsbach burial chapel, the carved Rococo pulpit, and the generous Stumm organ (installed 1765-1767).
The castle church is classified as a cultural monument worthy of special protection according to the Hague Convention for the Protection of Cultural Property in the event of armed conflict in Rhineland-Palatinate.